In this action-packed thriller based on the popular video game series, something terrible is lurking in the Hive, a vast underground research facility. A deadly viral outbreak occurs, and in response, the Red Queen; a supercomputer that controls the Hive, seals the entire facility to contain the leak, killing all the trapped employees. When Alice (Milla Jovovich) and Rain (Michelle Rodriguez) lead a commando team to isolate the virus, they soon discover that the workers are not really dead; they are now the ravenous Undead, from whom one bite or scratch brings instant transformation into their kind. Alice and the task force have three hours in which to pass through a series of horrifying obstacles to complete their mission before the virus threatens to overrun the Earth.